PTGES3 抗体Applications
| In-house applications |
ELISA, IF, IP, WB, FC Application not tested? Please see our Guarantee. |
| Species specificity |
Human,Mouse,Rat; other species not tested. |
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Images
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 rat brain tissue were subjected to SDS PAGE followed by western blot with 15216-1-AP( PTGES3 Antibody) at dilution of 1:1000 Immunofluorescent analysis of Hela cells, using PTGES3 antibody 15216-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). IP Result of anti-PTGES3 (IP:15216-1-AP, 3ug; Detection:15216-1-AP 1:300) with mouse heart tissue lysate 4000ug. 1X10^6 HeLa cells were stained with 0.2ug PTGES3 antibody (15216-1-AP, red) and control antibody (blue). Fixed with 90% MeOH blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1000.
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| Positive WB detected in |
Rat brain tissue, mouse brain tissue, mouse heart tissue, rat heart tissue |
| Positive IP detected in |
Mouse heart tissue |
| Positive IF detected in |
Hela cells |
| Positive FC detected in |
HeLa cells |
| Recommended dilution |
WB : 1:500-1:5000
IP : 1:200-1:1000
IF : 1:10-1:100 |
PTGES3 抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
| Source |
Rabbit |
Purification method |
Antigen affinity purification |
| Isotype |
IgG |
Storage |
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information PTGES3 抗体
| Immunogen |
PTGES3 fusion protein ag7384 |
Full name |
Prostaglandin E synthase 3 (cytosolic) |
Calculated molecular
weight |
19 kDa |
Observed molecular
weight |
21-23kd |
GenBank accession
number |
BC003005 |
Gene ID (NCBI) |
10728 |
| Gene symbol |
PTGES3 |
Synonyms |
CPGES, Hsp90 co chaperone, P23, Prostaglandin E synthase 3, PTGES3, TEBP, Telomerase binding protein p23 |
Background
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P23, encoded by the gene PTGES3, plays a key role in glucocorticoid signaling and was increased at the mRNA level in the DLPFC in individuals with schizophrenia (PMID: 24345775). In the GR heterocomplex in vitro, p23 is an obligatory co-factor19 and is the limiting component of the complex44, functioning to stabilize the interaction of the complex with GR in the cytoplasm. Paradoxically, p23 also acts in the nucleus to inhibit GR-mediated gene transcription and disassemble GR transcriptional machinery in the nucleus (PMID: 12077419). In vivo, p23 is critical for appropriate glucocorticoid responsiveness (PMID: 17000766). PTGES3 抗体
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