Calsequestrin,肌钙集蛋白/收钙素抗体

产品编号HZ-2961R
英文名称Calsequestrin
中文名称肌钙集蛋白/收钙素抗体
别 名CASQ; Calsequestrin 1; Calsequestrin 1 fast twitch skeletal muscle; Calsequestrin 2; Calsequestrin 2 fast twitch cardiac muscle; Calsequestrin cardiac muscle isoform; Calsequestrin skeletal muscle isoform; Cardiac calsequestrin 2; CASQ 1; CASQ 2; PDIB1; PDIB2; Skeletal muscle calsequestrin 1.
说 明 书0.1ml 0.2ml
研究领域心血管 信号转导 转录调节因子 结合蛋白 线粒体
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Pig, Cow, Horse, Rabbit,
Calsequestrin,肌钙集蛋白/收钙素抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量40kDa
细胞定位细胞浆 线粒体
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Calsequestrin
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Calsequestrin,肌钙集蛋白/收钙素抗体PubMedPubMed
产品介绍background:
The sarcoplasmic reticulum (SR) is, in part, responsible for maintaining the level of intracellular calcium in cardiac and skeletal muscle by storing and releasing calcium. Several intralumenal SR calcium binding proteins have been identified, the most prominent of these is calsequestrin. Calsequstrin is a calcium binding protein known to sequester calcium accumulated in the sarcoplasmic reticulum of muscle cells during relaxation and is found discretely localized to the junctional and corbular (terminal cisternae) SR. Calsequestrin functions to localize calcium near the junctional face of the terminal cisternae from which calcium can be released into the cytosol via the ryanodine receptor. This protein is highly acidic and has a large capacity and moderate to low affinity for calcium.

Function:
Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. The skeletal muscle isoform (CASQ1) binds around 80 Ca(2+) ions, while the cardiac isoform (CASQ2) binds approximately 60 Ca(2+).

Subcellular Location:
Sarcoplasmic reticulum lumen. Mitochondrion. Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of fast skeletal muscle cells. Also mitochondrial according to PubMed:7945294.

Similarity:
Belongs to the calsequestrin family.

Gene ID:
844

Calsequestrin,肌钙集蛋白/收钙素抗体Database links:
Entrez Gene: 844 Human
Entrez Gene: 12372 Mouse
Entrez Gene: 686019 Rat
Omim: 114250 Human
SwissProt: P31415 Human
SwissProt: O09165 Mouse
SwissProt: P19633 Rat
Unigene: 632476 Human
Unigene: 12829 Mouse
Unigene: 159963 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

肌钙集蛋白，隐钙素，收钙素，是肌浆网上调控钙储存的主要结合蛋白。CASQ与内质网钙结合蛋白肌钙网蛋白具有同源性（calreticulin）。CASQ1主要在快收缩骨骼肌表达，CASQ2主要在在慢收缩骨骼肌和心肌表达。