NNMT polyclonal antibody
产品名称： NNMT polyclonal antibody
英文名称： NNMT polyclonal antibody
产品编号： PAB2193
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of NNMT.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to internal region of human NNMT.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein A purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-100)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Search for the tumor-associated proteins of oral squamous cell carcinoma collected in Taiwan using proteomics strategy.
Liao KA, Tsay YG, Huang LC, Huang HY, Li CF, Wu TF.J Proteome Res. 2011 Feb 16. [Epub ahead of print]
- 2.
- Histone deacetylase inhibitor depsipeptide represses nicotinamide N-methyltransferase and hepatocyte nuclear factor-1beta gene expression in human papillary thyroid cancer cells.
Xu J, Hershman JM.Thyroid. 2006 Feb;16(2):151-60.
- 3.
- Identification of nicotinamide N-methyltransferase as a novel serum tumor marker for colorectal cancer.
Roessler M, Rollinger W, Palme S, Hagmann ML, Berndt P, Engel AM, Schneidinger B, Pfeffer M, Andres H, Karl J, Bodenmuller H, Ruschoff J, Henkel T, Rohr G, Rossol S, Rosch W, Langen H, Zolg W, Tacke M.Clin Cancer Res. 2005 Sep 15;11(18):6550-7.
- 4.
- A genomewide exploration suggests a new candidate gene at chromosome 11q23 as the major determinant of plasma homocysteine levels: results from the GAIT project.
Souto JC, Blanco-Vaca F, Soria JM, Buil A, Almasy L, Ordonez-Llanos J, Martin-Campos JM, Lathrop M, Stone W, Blangero J, Fontcuberta J.Am J Hum Genet. 2005 Jun;76(6):925-33. Epub 2005 Apr 22.
- Applications
- Western Blot (Transfected lysate)
- Western blot analysis of NNMT (arrow) using rabbit NNMT polyclonal antibody (Cat # PAB2193). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the NNMT gene (Lane 2) (Origene Technologies).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma reacted with NNMT polyclonal antibody (Cat # PAB2193) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
- Entrez GeneID:
- 4837
- Protein Accession#:
- NP_006160;P40261
- Gene Name:
- NNMT
- Gene Alias:
- -
- Gene Description:
- nicotinamide N-methyltransferase
- Omim ID:
- 600008
- Gene Ontology:
- Hyperlink
- Gene Summary:
- N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq
- Other Designations:
- -
- Related Disease
- Aortic Aneurysm, Abdominal
- Atherosclerosis
- Brain Ischemia
- Cleft Lip
- Cleft Palate
- Ductus Arteriosus, Patent
- Genetic Predisposition to Disease
- Heart Defects, Congenital
- Hyperhomocysteinemia
- Infant, Premature, Diseases
- Migraine Disorders
- Migraine with Aura
- Prenatal Exposure Delayed Effects
- Spinal Dysraphism
- Stroke